Study on Animal Pharmacokinetics of Matrine
- VernacularTitle:苦参碱的动物药代动力学研究
- Author:
Jingping ZHU
;
Daming DENG
;
- Publication Type:Journal Article
- Keywords:
animal pharmacokinetics;
matrine;
HPLC;
two-compartment open model
- From:
Chinese Traditional Patent Medicine
1992;0(06):-
- CountryChina
- Language:Chinese
-
Abstract:
The authors determined the concentration of matrine in rabbit blood plasma with HPLC after it was injected intravenously at constant rate and studied the pharmacokinetics with following five dosage groups of 10,15,20,30 and 60 mg/kg,respectively.As a result,the pharmacokinetics of matrine in rabbit body coincides with two-compartment open model.For 10-30mg/kg dosage groups,the t_(1/2)?,Vc and CLS are similar basically. A direct proportion increase in AUC as dose is increased.The matrine reveals linear elim- ination.For 60 mg/kg dosage group,t_(1/2)? obviously lengthens.AUC increases over pro- portion.The elimination of matrine is nonlinear.
