THE DISTRIBUTION,ORIGIN AND PROPERTIES OF ACH,NE,CGRP.VIP AND NPY IN TONGUE OF RATS
- VernacularTitle:大鼠舌内ACh、NE、CGRP、VIP和NPY的分布、来源及性质的研究
- Author:
Jingui SHAO
;
Wenqin CAI
;
- Publication Type:Journal Article
- Keywords:
Rat;
Tongue;
CGRP;
VIP;
NPY;
Histochemistry;
Immunocytochemistry
- From:
Acta Anatomica Sinica
1989;0(S1):-
- CountryChina
- Language:Chinese
-
Abstract:
By using histochemical and immunocytochemical techiques, the distribu- tion, origin, and properties of ACh, NE, CGRP, and NPY in tongue of rats were studied. The results revealed that the cholinergic (ACh) nerves, VIP and NPY im- munoreactive (IR) positive neurons mainly located in the subepithelial layer of the mucosa and the muscle layer. The nerves formed perivascular plexus of the blood vessels, surrounding the glands, and distributed in the muscle layer. The adrenergic nerves surrounded the blood vessels and gaglion cells forming a basket-like structure. CGRP-IR nerves were observed in all layers of tongue. The circumvallate and fungiform papillaes were densely innervated by the CGRP-IR nerves, whereas the filiform papillaes contained only a few nerves. Abundant CGRP-IR nerves surrounded the glands, the blood vessels, and formed motor end plate structure at the region of contacting the striated muscle of to- ngue. After treatment with capsaicin, a marked reduction in the CGRP-IR ner- ves were found in the mucosa of the tip and body of the tongue, but no ob- vious changes were seen in the other parts of the CGRP-IR nerves as well as the other type of the nerves. No NE and CGRP-IR neurons were observed. The characteristics of distribution suggested that the ACh,VIP and NPY nerves might be related to the regulation of regional blood flow and the secretion of the glands while the CGRP-IR nerves, besides the above effects, might be related to the regulation of motion and sensation.
