THE DISTRIBUTION AND CHANGES OF CALCITONIN-GENE-RELATED PEPTIDE IMMUNOREACTIVE NERVES IN THE TONGUE OF RAT AND THEIR CHANGES DURING ACUTE INTESTINAL RADIATION SICKNESS
- VernacularTitle:大鼠舌内降钙素基因相关肽免疫反应性神经的正常分布及其在肠型放射病时的变化
- Author:
Jingui SHAO
;
Wenqin CAI
;
- Publication Type:Journal Article
- Keywords:
Tongue;
Acute intestinal radiation sickness;
Calcitonin gene-related peptide;
Immunocytochemistry
- From:
Acta Anatomica Sinica
1989;0(S1):-
- CountryChina
- Language:Chinese
-
Abstract:
The changes of calcitonin gene-related peptide (CGRP) immunoreactive (IR) nerves in the tongue of the control and the irradiated rats were studied by using the methods of immunocytochemistry and microspectrophotometer (SPM) measuring techniques. The results show that CGRP-IR nerves were found in all tissues of the tongue. When acute intestinal radiation sickness (AIRS), the changes of CGRPIR nerves appeared obviously and might be divided into two phases: the stimulating phase was the first 24 hours after irradiation. CGRP-IR nerves of the tongue have obviously swollen, become thickness, the enlargement of the varicosities and an increase of accumulative material in the nerve fiber terminals. The destructive phase was from 24 to 72 hrs after irradiation. The characteristics of the lesion appeared in 48 hrs after irradiation. CGRP-IR nerves of the tongue body have reduced, part of CGRP-IR nervous bundles broken. The pathological changes were particularly evident in 72 hrs after irradiation. CGRP-IR nerves of the tongue body have marked reduced, even disappeared. All of CGRP-IR nerves of the root of the tongue almost broken completly with the exception of the structure like the motor end plates of the striated muscles and the CGRP-IR nerves in taste glands. By using SPM measuring, there was significant reduction in 48 hrs or 72 hrs after irradiation compared with the control group (P
