The Effect of Bone Marrow Mononuclear Cells Transplantation on Myocardial Apoptosis after Acute Myocardial Infarction in Rats.
- VernacularTitle:同种异体骨髓干细胞移植对急性心肌梗死后大鼠心肌细胞凋亡基因的影响
- Author:
Ruicheng ZHANG
;
Gang WU
;
Jianfeng HOU
;
Rujun ZHU
;
Jianwei WANG
;
Xia GAO
;
Kai LIANG
;
Baocai WANG
;
Jiangjiang RU
- Publication Type:Journal Article
- Keywords:
Acute myocardial infarction;
Bone marrow mononuclear cells;
Cellualr transplantation;
Myocardial cellular apoptosis;
Myocardial apoptosis index;
TNF-?;
PDCD5 mRNA
- From:
Journal of Medical Research
2006;0(02):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the effect of allogenic bone marrow mononuclear cells(BM-MNCs) transplantation on myocardial apoptosis after acute myocardial infarction(AMI) in rats.Methods 40 Wistar rats were randomly divided into control group(n=20) and transplantation group(n=20).Myocardium around the infarcted left ventricular area of the rats in transplantation group were injected with BM-MNCs suspension beneath the epicardium.Myocardium the area of control group was injected with culture solution.Results After 4 weeks of the operation,the myocardial apoptosis index,the TNF-? content and the PDCD5 mRNA of transplantation group were all notably less than those of control group(P
