Study on Anti-stress Activity of Thymopentin Ethyl Ester
- VernacularTitle:胸腺五肽乙酯的抗应激作用研究
- Author:
Qiang CHI
;
Peng XU
;
Lina DU
;
Shan LA
;
Zhongshan LUAN
;
Junyang XU
;
Lili WANG
;
Zhi YANG
;
- Publication Type:Journal Article
- Keywords:
Thymopentin ethyl ester;
Stress;
Corticoid;
IL-2;
SOD
- From:
Journal of Medical Research
2006;0(11):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the anti - stress activity of thymopentin ethyl ester. Methods Anti - stress activity was evaluated by heat stress model and chronic uncontrolled stress model. Heat stress model;of 60 KM mice were divided into six groups. Except the controlled group, the other mice were maintained in 42℃ for 1h. Chronic uncontrolled stress model:of 60 KM mice were divided into six groups. Except the controlled group, the other mice were given three different stimulations once a day for continuous 21 d. The controlled group and model group were injected saline 0.2ml, and the three test groups were respectively injected thympentin ethyl ester at 2mg/kg,0.2mg/kg, 0.02mg/kg subcutaneously. The positive controlled mice were given thymopentin 0.2mg/kg subcutaneously. At the end of the experiment, plasma corticosteroid, IL -2 and SOD were determined according to the kit instructions. Results The activities of thymopentin ethyl ester in suppressed corticosteroid up - regulation and the elevated plasma IL - 2 and SOD level were more significant than those of thymopentin(P
