Correlation of expressed TopoⅡ? and Ki-67 with the prognosis of uterine sarcoma
- VernacularTitle:拓扑异构酶Ⅱ?和Ki-67表达与子宫肉瘤预后的相关性研究
- Author:
Yang SUN
;
Li′An LI
;
Lei SONG
;
Shoulan ZHU
;
- Publication Type:Journal Article
- Keywords:
sarcoma;
uterine neoplasms;
prognosis;
cell proliferation;
DNA topoisomerases, type Ⅱ;
Ki-67 antigen
- From:
Medical Journal of Chinese People's Liberation Army
2001;0(11):-
- CountryChina
- Language:Chinese
-
Abstract:
25%) and low LI groups (positive cell rate ≤25%) of TopoⅡ? and Ki-67. However, in high LI groups, the overall survival rate was lower than those in low LI groups (P=0.002, P=0.004, Log-Rank test), the volume of recurred masses was bigger (P=0.005, P=0.000) and recurrence time was shorter (P=0.000, P=0.000) than those in low LI groups. There existed a significant linear correlation between the expressions of TopoⅡ? and Ki-67 (r=0.935 5, P=0.000). The expressions of TopoⅡ? and Ki-67 were related with pathological category and staging (P0.05). Conclusions Both TopoⅡ? and Ki-67 could be used as specific markers of cell proliferation, but the specificity of TopoⅡ? might be higher than that of Ki-67 in accurately reflecting the cell proliferation. TopoⅡ?, combined with pathological category and staging, may play an important role in prognostic prediction of uterine sarcoma.
