Ramiprii in combination with irbesartan for treatment of chronic heart failure in patients with rheumatic heart disease
- VernacularTitle:厄贝沙坦联合雷米普利在风湿性心脏病慢性心力衰竭患者中的作用
- Author:
Ping DING
;
Li LI
;
Zhi-Yun XU
;
Lin HAN
;
Bin HE
;
- Publication Type:Journal Article
- Keywords:
irbesartan;
ramipril;
chronic heart failure;
rheumatic heart disease
- From:
Academic Journal of Second Military Medical University
1985;0(06):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the effectiveness of irbesartan in combination with ramipril for treatment of chronic heart failure in patients with rheumatic heart disease(RHD).Methods:A total of 120 RHD patients with chronic heart failure were randomized into treatment group(n=60)and control group(n=60)after valve replacement.All patients received regular ramipril treatment(5 mg/d);treatment group were also given irbesartan(150 mg/d).The patients were followed up for 6 months.The indices of observation included cardiac function(NYHA Class),6-Minute Hall Walk distance,and echocardiographie parameters.Results:Six months later the cardiac function in the treatment group was obviously improved compared with the control group;the patients in the treatment group had significant increase in 6-Minute Hall-Walk distance and improvement in echocardiographic parameters(left ventricle end-systolic diameters,end-diastolic diameter,ejection fraction, fractional shortening,P
