A meta-analysis of therapeutic effect of cyclosporine microemulsion and tacrolimus for patients undergoing liver transplantation
- VernacularTitle:肝移植术后环孢素微乳剂与他克莫司疗效比较Meta分析
- Author:
Liang XIAO
;
Hong FU
;
Zhi-Jia NI
;
Guo-Shan DING
;
Xiao-Min SHI
;
Wen-Yuan GUO
;
Jiang-Ping XIE
;
Wei LIU
;
Jie-Yu YANG
;
Xiao-Gang GAO
;
Jun MA
;
Zhengxin WANG
;
Zhiren FU
;
- Publication Type:Journal Article
- Keywords:
cyclosporine microemulsion;
tacrolimus;
liver transplantation;
Meta-analysis
- From:
Academic Journal of Second Military Medical University
1985;0(06):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To evaluate the efficacy and safety of microemulsified cyclosporine(Neoral)and tacrolimus(FK506) for immunodepression after Iiver transplantation.Methods:According to the including criteria,fifteen randomized controlled trials were enrolled in this analysis.The data of trial design,characteristics of the subjects,and findings of the studies were reviewed and analyzed by RevMan 4.2.8 software.Results:The patient survival rate,graft survival rate,incidence of nephrotoxicity,and incidence of infection were not significantly different between Neoral and FK506 groups,with the relative risk and(95% CI,P)being 0.99(0.96-1.02,0.37),0.97(0.92-1.03,0.30),0.99(0.87-1.13,0.86)and 1.08(0.97-1.20, 0.16),respectively.The incidences of hypertension(1.34[1.15-1.55,0.000 1])and acute rejection(1.15[1.06-1.25,0.001]) were significantly lower in the FK506 group,with no significant difference found in the degree of acute rejection(1.00[0.92- 1.22],0.98).Interestingly,the incidence of diabetes was significantly higher in the FK506 group within 1 year after the operation,but was similar to that of the Neoral group thereafter,with relative risk(95%CI,P)being 0.72(0.62-0.83,
