Studies on the metabonomics of rat liver injury induced by ethanol and interfering effects of Yin Chen Hao Tang
- VernacularTitle:乙醇诱导大鼠肝损伤的代谢组学和茵陈蒿汤的干预研究
- Author:
Xi-Jun WANG
;
Lian LIU
;
Hui SUN
;
Wen-Jun SUN
;
Hai-Tao LV
;
- Publication Type:Journal Article
- Keywords:
UPLC-Q-TOF/MS;
metabonomics;
biomarker;
Yin Chen Hao Tang;
liver injury
- From:
Chinese Pharmacological Bulletin
1986;0(04):-
- CountryChina
- Language:Chinese
-
Abstract:
Aim To determine potential biomarkers contributed to occurrence, development and recovery of ethanol-induced liver injury in rat and elucidate hepatoprotective effect of Yin Chen Hao Tang based on metabonomic investigation. Methods A UPLC-Q-TOF/MS based metabonomic method was developed for investigating trajectory change and inter-relationship of urinary metabolome of rats with different treatments. Results Four potential biomarkers were determined which contributed to occurrence, development and recovery of ethanol-induced liver injury in rat, and Yin Chen Hao Tang could significantly recover trajectory change in disorder. Conclusion The developed method was successfully applied to investigate ethanol-induced liver injury in rat, and also hepatoprotective effect of Yin Chen Hao Tang was elucidated.
