Effects of Xuebijing on the expression of ICAM-1 and its counterreceptor LFA-1 in acute necrotizing pancreatitis of rats
- VernacularTitle:血必净对ICAM-1及其配体LFA-1在大鼠急性坏死性胰腺炎中表达的影响及意义
- Author:
Wei SUN
;
Fang WEI
;
Lin GUO
;
Qiang WANG
;
- Publication Type:Journal Article
- Keywords:
Xuebijing injection;
Acute necrotizing pancreatitis;
ICAM-1;
LFA-1
- From:
Chinese Journal of Primary Medicine and Pharmacy
2006;0(12):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the effects of Xuebijing injection on the production of ICAM-1 and its counterreceptor(LFA-1)in ANP of rats at different time points.Methods ANP was induced by multiple points in- jection of 5% chenodeoxycholic acid into the pancreas,followed by ligation of pancreatic duct.Expressions of ICAM- 1 at different time points were assessed by immunohistochemistry method,the expressions of LAF-1 on neutrophils at different time points were detected by flow cytometer.The effect of Xuebijing injection was also evaluated by de- tecting the output of ascitic fluid,amylase level and histological changes in pancreas and lungs.Results The expres- sions of ICAM-1 in pancreas and lung of Xuebijing injection group decreased significantly than those in ANP group at most time points during the research period(P
