Protective effect of physcione on acute liver injury in rats
- VernacularTitle:大黄素甲醚对大鼠急性肝损伤的保护作用
- Author:
Li-Yan ZHANG
;
Wen-Hui SU
;
Ying XIONG
;
Dan WANG
;
- Publication Type:Journal Article
- Keywords:
Physcione;
Liver injury;
Tumor necrosis factor;
Rat
- From:
Chinese Journal of Primary Medicine and Pharmacy
2006;0(12):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the protective effect of physcione on acute liver injury in rats.Methods Acute liver injury rat model was constructed with 2ml/kg CCl_4((?)3 d)via intragastric administration.The serum concentrations of alanine aminotransferase(ALT),aspartate aminotransferase(AST)and tumor necrosis factor (TNF)in different groups were detected.Hepatic histopathology of different groups was also observed to reflect the effect of physcione.Results The serum concentrations of ALT,AST and TNF in physcione group were significantly lower than those of model group(P
