Clinical study on the treatment of diarrhea-predominant irritable bowel syndrome with small-dose ranitidine and diphenoxylate compositae
- VernacularTitle:小剂量盐酸雷尼替丁加复方地芬诺酯治疗腹泻型肠易激综合征的临床研究
- Author:
Shi-Jian LU
;
Zhi-Li WANG
;
- Publication Type:Journal Article
- Keywords:
Irritable bowel syndrome;
Raniridine hydrochloride;
Diphenoxylate compositae
- From:
Chinese Journal of Primary Medicine and Pharmacy
2006;0(12):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the clinical efficacy of small-dose ranitidine hydrochloride and diphenoxy- late compositae in the combined treatment of diarrhea-predominant irritable bowel syndrome(D-IBS).Methods A prospective,randomized controlled clinical trial was designed.150 D-IBS patients according to RomeⅡcriteria were randomly divided into combined treatment group and control group.The combined treatment group(74 patients)re- ceived ranitidine hydrochloride,0.15g,each evening and diphenoxylate compositae,1 piece,each evening.The control group(76 patients)received diphenoxylate compositae,1 piece,rid.This study consisted of a 2-week baseline period, a 3-week treatment period,followed by a 2-week follow-up period.The main efficacy variable was assessed by per- ception of overall symptom during the previous weeks.Secondary efficacy variables included severity of diarrhea,ab- dominal pain and distention and other symptoms.Results After treatment of 3 weeks,the efficacy of the combined treatment group was better than that of the control group(x~2=5.10,P
