Influence of isehemic preconditioning on the expression of caspase-3 after brain ischemia again
- VernacularTitle:缺血预处理对再缺血后脑组织caspase-3表达的影响
- Author:
Xin-Li ZHANG
;
Lin YIN
;
- Publication Type:Journal Article
- Keywords:
Ischemia preconditioning;
Brain;
caspase-3
- From:
Chinese Journal of Primary Medicine and Pharmacy
2006;0(12):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate effects of cerebral isehemic preconditioning on neurological function,in- farct volume,and the expression of caspase-3 in brain issue after brain ischemia again,and to investigate the brain protection mechanism produced by cerebral ischemia preconditioning.Methods 48 healthy male Sprague-Dawley (SD)rats(weighted 200～250g)were randomly divided into 2 groups:ischemia group(n=24),ischemia precondi- tioning group(namely preconditioning group,n=24).Each group was divided into 4 subgroups according to 6h,1d, 2d,4d after ischemia again.Results At the same point of time after ischemia,neurological deficit in preconditioning group was much less than that in ischemia group,the difference was significant(P
