Pnehyclidine hydrochloride as anticholinergic drug to treat severe acute organophosphorus pesticide poisoning
- VernacularTitle:盐酸戊乙奎醚治疗重度急性有机磷农药中毒
- Author:
Min-Jie MAO
;
Kun FANG
;
Yi-Hua ZHENG
;
- Publication Type:Journal Article
- Keywords:
Organophosphorus pesticides;
Poisoning;
Atropine;
Pnehyclidine hydrochloride
- From:
Chinese Journal of Primary Medicine and Pharmacy
2006;0(12):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To determine the effect of pnehyclidine hydrochloride as anticholinergic drug during the treatment of severe acute organophosphorus pesticide poisoning(SAOPP)and evaluate the safety.Methods 78 SAOPP patients was divided into control group(n=37)and test group(n=41).Atropine was as anticholinergic drug in control group and was replaced by pnehyclidine hydrochloride in test group.The persistence time of mus- carinic action,drug adverse reaction,severe complication,healing rate and therapeutic time of detoxification after these drugs being administered were observed in the two groups.Results The persistence time of muscarinic action was shorter in rest group than in control group(P
