Effects of trimetazidine on myocardial ischemia and heart rate variability in patients with non ST-elevation acute coronary syndrome
- VernacularTitle:曲美他嗪对非ST段抬高急性冠脉综合征患者心肌缺血和心率变异的影响
- Author:
Jing ZHANG
;
Sheng-Hu HE
;
Shu CHEN
;
Yi ZHANG
;
Feng-Di YAN
;
Jian-Feng YAN
;
Fu-Quan ZHAO
;
Xiao-Hua XU
;
- Publication Type:Journal Article
- Keywords:
non-ST-elevation acute coronary syndrome;
trimetazidine;
myocardial ischemia;
heart rate variability
- From:
Chinese Journal of Clinical Pharmacology and Therapeutics
2004;0(12):-
- CountryChina
- Language:Chinese
-
Abstract:
AIM:To observe the effects of trimetazi- dine on myocardial ischemia and heart rate variability (HRV)in patients with non ST-elevation acute coronary syndrome(NSTEACS).METHODS:74 patients with NSTEACS were chosen and randomly assigned into two groups:one group was given conventional therapy with as- pirin,isosorbide mononitfate,fluvastatin and metoprolol, trimetazidine was added on the base of conventional thera- py in the other group.The total observation time of thera- py was 8 weeks.The heart rote,blood pressure,frequen- cy and persistence time of chest pain,numbers of times of using Nitroglycerin every day,the extent anti degree of myocardial isehemia,HRV of patients were observed be- fore and after treatment.RESULTS:The therapeutic ef- fect of trimetazidine treatment group(with the effective rate 94.4%,excellence rate 72.2%)was obviously bet- ter than that of the conventional treatment group(with the effective rate 65.8%,excellence rate 36.8%)(P
