A clinical study on coadministration of Cyclosporin A and berberin hydrochloride in renal transplanted recipients
- VernacularTitle:肾移植受者环孢素A与盐酸小檗碱合用的临床研究
- Author:
Ai-Rong YU
;
Hua-Wen XIN
;
Xiao-Chun WU
;
Qing LI
;
- Publication Type:Journal Article
- Keywords:
renal transplantation;
Cyclosporin A;
berberin hydrochloride;
drug concentration in blood;
clinical study
- From:
Chinese Journal of Clinical Pharmacology and Therapeutics
2004;0(12):-
- CountryChina
- Language:Chinese
-
Abstract:
AIM:To study the effect of berberin hydrochloride(Ber)on the elevation of blood concentra- tion of Cyclosporin A(CsA)and liver and renal functions in renal transplanted recipients.METHODS:138 cases with renal transplantation in experimental group were treated with CsA and Ber and 150 cases with renal trans- plantation in control group received CsA only.Blood lev- els of CsA,biochemistry indexes for liver and renal func- tion were determined.RESULTS:After 1,3,6 months combined with Ber,blood concentrations of CsA in pa- tients went up by 49.8%,81.4%,36.9% and the radios of blood concentration of CsA to CsA dosage increased 88.8%,102.0%,72.5% compared with those before taking Ber(P
