Analysis of HBV precore 1896 site mutation and its HBV genotype and other laboratory features
- VernacularTitle:乙型肝炎病毒前C区1896点突变、基因分型及其实验室特征分析
- Author:
Qiang JI
;
Chun-Fang GAO
;
Yun-Peng ZHAO
;
Ying LU
;
Ai-Hua WANG
;
Si-Jia CHEN
;
- Publication Type:Journal Article
- Keywords:
point mutation;
genotype;
hepatitis B virus
- From:
Academic Journal of Second Military Medical University
1999;0(12):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To analyze the relationship between hepatitis B virus(HBV)gene mutation at 1896 in precore region with genotype and replication of HBV and the liver function of patients.Methods:HBV precore 1896 site mutation,the genotype of HBV and serum content of HBV DNA were determined by PCR in 60 patients positive of HBV DNA.Chemiluminescence miacropaticle immunoassay(CMIA)was used for detection of serum HBeAg and HBeAb.Liver function parameters were ob- tained by routine biochemistry method.Results:The alanine aminotransferase(ALT)level in HBV with 1896 site mutation was significantly higher than that in the wildtype virus.Site mutation at 1896 had no correlation with HBeAg,HBV genotype and HBV DNA content.HBV DNA content in patient with genotype C was significantly higher than that with genotype B(P
