Mechanisms of Homocysteine Neurotoxicity
- VernacularTitle:同型半胱氨酸的神经毒性机制
- Author:
Li-Shu WAN
;
Yan REN
;
- Publication Type:Journal Article
- Keywords:
homocysteine;
hyperhomocysteinemia;
neurotoxicity
- From:
International Journal of Cerebrovascular Diseases
2006;0(12):-
- CountryChina
- Language:Chinese
-
Abstract:
Growing evidence indicates that hyperhomocysteinemia is not only a high risk factor for cerebrovascular diseases,but also closely correlated with neurodegenerative diseases and mental diseases,such as Alzheimer's disease,Parkinson's disease,dementia,cognitive impair- ment,depression and schizophrenia,The mechanisms of homocysteine neurotoxicity remains unclear,and it may include activating extracellular signal-regulated kinases,excessively activating glutamate receptors,participating in oxidative stress response,affecting methylation process and damaging DNA.
