Clinical significance on the changes in L-Arginine/NO synthase/NO pathway in platelets of pilots,submarine sailors,and land servicemen
- VernacularTitle:飞行员与潜艇艇员血小板L-精氨酸/一氧化氮合酶/一氧化氮系统变化的临床意义
- Author:
Lianru GAO
;
Ningkun ZHANG
;
Qingai DING
;
Al ET
;
- Publication Type:Journal Article
- Keywords:
military personnel;
blood platelets;
arginine;
nitric-oxide synthase
- From:
Medical Journal of Chinese People's Liberation Army
2001;0(12):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To discuss the influence of several physico-chemical factors existed in the surrounding environment on the endothelium function of pilots,submarine sailors and ground crew,so as to provide a basis for preventing the cardiovascular disease.Methods 48 submarine sailors(SM group),22 pilots(PI group)and 17 ground crew(control group),all of them were healthy males,were chosen as the subjects.The dynamic features of 3H-L-Arg in the platelets transportation were checked with isotope labeling technique.The yielded nitrite(NO-2),a product of NO metabolism,and the activity of NO synthase(NOS)in platelets were detected.Results In SM group,the ability of L-Arg transportation in platelets was much lower than that of both control group and PI group.The maximum transport velocity(Vmax)of SM group was lower by 31.4% than that of control group(P
