Effect of Chinese herb Yiyanheji on intestinal mucosa barrier in rats with severe acute pancreatitis
- VernacularTitle:胰炎合剂对大鼠重症急性胰腺炎肠屏障影响的实验研究
- Author:
Jun-Shan YANG
;
Yan ZUO
;
Li-Ming HAN
;
Yu-Zhi TIAN
;
Yu HOU
;
- Publication Type:Journal Article
- Keywords:
Pancreatitis;
Drugs;
Chinese herbs;
Bacterial translocation;
Intestinal mucosa
- From:
Chinese Journal of Primary Medicine and Pharmacy
2005;0(11):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the effects of Chinese herbs Yiyanheji on intestinal mucosa barrier in rats with SAP.Methods Animal models of SAP were induced by retrograde injection of 5% sodium taurocholate (0.1ml/100g) into the common biliopancreatic duct.90 healthy Wistar rats weighing (250?30)g were randomly divided into 3 groups:sham operation group (SO,n=30),SAP group (SAP,n=30) and Chinese herbs Yiyanheji treated group(SAP+YH,n=30).Treated group was treated with Yiyanheji after operation.The SAP group was treated with physiological saline.Three groups of rats were killed at 72 hours after operation or treatment.Bacterial cultures were performed in all animals.The changes of terminal ileum' tissue were observed by optical electron mi- croscopy.The data of test were analyzed by statistic software.Results The incidence of bacterial translocation was 22.5% in Yiyanheji treated group,and it was lower than that in SAP group which was 90.0 %.The difference was significant(P
