Preparation of nimodipine-loaded PLEG copolymer nanoparticles and quality evaluation
- VernacularTitle:包载尼莫地平的聚乳酸-聚乙二醇嵌段共聚物纳米粒的制备和质量评价
- Author:
Ying FAN
;
Chen ZHOU
;
Wen-Sheng LIU
;
- Publication Type:Journal Article
- Keywords:
Nanotechnology;
Polyethylene glycols;
Nimodipine
- From:
Chinese Journal of Primary Medicine and Pharmacy
2005;0(11):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To improve the poor water-solubility of nimodipine,nimodipine-loaded PLEG copoly- met nanopartieles were prepared to avoid the sedimentation of its crystal from water,which could also shun the blood vessel stimulation caused by ethanol,a cosolvent,in the injection.Methods Solvent evaporation method was used to prepare water-dispersing nimodipine-loaded nanoparticles,whose lyophilized powder was further prepared,with PLEG2000 as drug carrier.Particle size,Zeta potential,embedding ratio,drug loading,shape and redispersion ability of the lyophilized powder were determined.Results Concerning the lyophilized nanoparticle powders,the particle sizes were 136nm,the Zeta potentials were -29.90mV,the embedding ratio was 67.9% and the drug loading was 6.17%.Conclusion Prepared nimodipine-loaded nanoparticles solved the problem of poor water-solubility of ni- modipine basically.It also avoided the recrystallization process of the drug and reduced the blood vessel stimulation caused by ethanol in the injection.
