Dihydromyricetin exerted its vasoconstrictive effects by increasing intracellular Ca~(2+) in isolated canine carotid artery
- VernacularTitle:二氢杨梅素通过增加细胞内钙而收缩离体犬颈动脉环
- Author:
Hui-Li NIU
;
Zhen-Wei PAN
;
Jiu-Xin ZHU
;
Sheng-Ji CAO
;
Lu-Chen SHAN
;
YAN-JIE
;
Bao-Feng YANG
;
- Publication Type:Journal Article
- Keywords:
dihydromyricetin;
vascular smooth muscle;
confocal laser scanning microscopy;
[Ca~(2+)]i
- From:
Chinese Pharmacological Bulletin
2003;0(11):-
- CountryChina
- Language:Chinese
-
Abstract:
Aim To investigate the effect of dihydromyricetin on canine carotid artery and the underlying mechanism.Methods The in vitro isometric tension measurement technique was employed to investigate the effect of dihydromyricetin on canine carotid artery rings.Laser scanning confocal microscope technique was used to measure the dynamic change of intracellular calcium concentration in single VSMC.Results Dihydromyricetin(1～300 ?mol?L-1)caused a concentration-dependent contraction of both endothelium-intact and endothelium-denuded rings.This constrictive effect was attenuated in Ca2+-free solution(P
