Study on Antihypertensive time-effect and dose-effect of Sancao Jiangya decoction on SHRs
- VernacularTitle:三草降压汤对自发性高血压大鼠降压作用的量效与时效关系研究
- Author:
Hui-Hua QU
;
Yan ZHAO
;
Rong-Bo QU
;
Er-Qun TANG
;
Yu-Hang LI
;
Qing-Guo WANG
;
- Publication Type:Journal Article
- Keywords:
Sancao Jiangya decoction;
Antihypertensive;
Timeeffect;
Dose-effect;
Experimental study
- From:
China Journal of Traditional Chinese Medicine and Pharmacy
2005;0(11):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To investigate the antihypertensive time-effect and dose-effect features of Sancao jiangya decoction(SCD).Methods: The blood pressure of spontaneously hypertensive rats at different time points were measured after treatment with Sancao jiangya decoction of low,middle,high concentration by tailartery blood pressure measurement for conscious rats.Results: The blood pressure was decreased at 2 hours after drug taken,there were significant dose-effect relationship between the antihypertensive effect and the low,middle,high dose.At 4h after drug taken,the high,middle dose had dose-effect correlation,but the low-dose had no antihypertensive effect.Further research on the middledose shows that the blood pressure reduced at 1h after drug taken,and the stable antihypertensive effect was keeping during 1-4h,the blood pressure began to rise at 6h,and got back to the level before drug taken at 8h.Conclusion: To choose the Middle-dose(10.4g crude drug/kg body weight) and 2h after drug taken is appropriate for SCD's use.This result laid a substantial foundation for further research on effects evaluation and mechanism of antihypertensive medicine.
