Expressions and significance of Survivin and VEGF in hepatocellular carcinoma
- VernacularTitle:生存素和血管内皮生长因子在肝癌中的表达及意义
- Author:
Kai-Fu KANG
;
Ai-Wen CHE
;
Xiao-Wu CHEN
;
Xiang-Cheng SHI
;
Jian-Ping CHEN
;
- Publication Type:Journal Article
- Keywords:
Survivin;
Vascular endothelial growth factor;
Liver neoplasms;
Immunohistochemistry
- From:
Chinese Journal of Primary Medicine and Pharmacy
2006;0(10):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the expressions of Survivin and VEGF and relationship between them in hepatocellular carcinoma(HCC).Methods The expressions of Survivin protein and VEGF protein in 50 HCC.30 cirrhosis and 10 normal tissues were assessed by immunohistochemical method.The expressions of Survivin mRNA and VEGF mRNA in 50 HCC,30 cirrhosis and 10 normal tissues were assessed by in situ hybridization.Results The expressions of Survivin and VEGF in cancer tissues,cirrhosis tissues,normal tissues weresignificantly different. The expression of Survivin in HCC tissues was stronger than that in cirrhosis,but the expreesion of VEGF in cirrho- sis was stronger than that in HCC tissues.Conclusion The expression of survivin.is closely associated with the ex- pression of VEGF in HCC and they take positive correlation.The abnormal expressions of Survivin and VEGF are closely associated with the development of HCC.They may play important roles in the development of HCC.
