The Effects of Ephrin Receptor B2 on Angiogenesis and Neuroplasticity in Areas Remote From the Cortical Infarction
- VernacularTitle:Ephrin B2受体对皮质脑梗死远隔部位血管发生和神经可塑性的影响
- Author:
Qing-Hua HOU
;
Jin-Sheng ZENG
;
- Publication Type:Journal Article
- Keywords:
epbrin receptor B2;
cerebral infarction;
angiogenesis;
neuroplasticity
- From:
International Journal of Cerebrovascular Diseases
2006;0(10):-
- CountryChina
- Language:Chinese
-
Abstract:
Cerebral infarction is not only a focal damage,but also causes secondary damage in areas remote from the ischemic territory,which will retard the recovery of neurological function.Ephrin receptor B2 (EphB2) plays an important role in the development and repair mechanism of central nervous system.Blocking the effect of EphB2 in brain by using a specific inhibitor may enhance proliferation and migration of endogeneous neuronal stem cells after experimental cerebral infarc- tion,improve neurological function and influence angiogenesis and neuroplasticity in remote sites.It is expected to become a new approach for decreasing damages in areas remote from the cerebral infarction and promoting the recovery of neurological function.
