Interference effect of Kangxianzengzhi capsule on hippocampal mossy fiber sprouting in epileptic rat kindled by pentylenetetrazol
- VernacularTitle:抗痫增智胶囊对戊四唑点燃大鼠海马苔藓纤维发芽的干预作用
- Author:
Rong MA
;
Chang-Ren SHI
;
Xin-Min LI
;
- Publication Type:Journal Article
- Keywords:
Epilepsy;
TCM therapy;
Kangxianzengzhi capsule;
Pentylenetetrazol(PTZ);
Mossy fiber sprouting;
Timm stain
- From:
China Journal of Traditional Chinese Medicine and Pharmacy
2005;0(10):-
- CountryChina
- Language:Chinese
-
Abstract:
To explore the interference effect of Kangxianzengzhi(KXZZ) capsule on hippocampal mossy fiber sprouting in epileptic rat kindled by pentylenetetrazol.Methods: Epileptic rat models were established by pentylenetetrazol(PTZ) kindling method.All rats were divided into six groups: KXZZ high-does group,KXZZ middle-does group,KXZZ low-does group,valproate magnesium group, model group and normal group randomly.Then the hippocampal mossy fiber sprouting was monitored by Timm stain method.Results: Mossy fiber sprouting was obvious in the hippocampal CA3 section and the molecular layer of dentate syrus in model group.Compared with normal group,the percent of sprouting density in model group was higher(P
