Expression of P16,CyclinD1 and P53 in hydatidiform mole and its significance
- VernacularTitle:P16、CyclinD1和P53在葡萄胎组织中的表达及意义
- Author:
Xue-Qin WU
;
Jin-Quan LIANG
;
De-Ju JIANG
;
Zheng ZHU
;
- Publication Type:Journal Article
- Keywords:
Hydatidiform mole;
Chorionic villi;
Immunohistochemistry;
Genes,P16;
Genes,P53
- From:
Chinese Journal of Primary Medicine and Pharmacy
2006;0(09):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the relationship between P16,CyclinD1 and P53 anti-oncogene and the gen- esis of hydatidiform mole.Methods 30 samples of hydatidiform moles and normal early pregnant aborted placenta villi respectively were obtained to detect the P16,CyclinD1 and P53 anti-oncogene expression in two kinds of tissues by using SP immunohistochemical staining.Results Compared with that of normal villi,the expressions of P16,P53 and CyclinD1 anti-oncogene were quite different in hydatidiform moles.The expression of P16 was all positive,while CyclinD1 and P53 were all negative in the chorion of early gestation.A descending tendency of P16 expression was found,while the expression of CyclinD1 showed an ascending tendency.The positive rate of P16,CyclinD1 and P53 expression was significantly different between the groups.It was also observed that there was significant difference between the P16 and the proliferation trophocyte.Conclusion P16,CyclinD1 and P53 anti-oncogene have a close relationship with the genesis of human hydatidiform mole.
