Clinical study on intravenous lidocaine suppressing fentanyl-induced cough
- VernacularTitle:不同剂量利多卡因预防芬太尼诱发咳嗽的临床研究
- Author:
Qi ZHOU
;
Shao-Chuan FU
;
Nai-Quan MA
;
Li CHEN
;
Yin-Hong GU
;
Chen-Hai WU
;
- Publication Type:Journal Article
- Keywords:
Lidocaine;
Fentanyl;
Cough
- From:
Chinese Journal of Primary Medicine and Pharmacy
2006;0(08):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the effects of different doses of lidocaine on suppressing fentanyl-induced cough and determine a safe suppressing dose.Methods Two hundred patients undergoing general anesthesia were randomized to four groups evenly.The following medications were given within ten seconds:normal saline 10ml (groupⅠ,control group),lidocaine 1 mg/kg (groupⅡ),lidoeaine 1.5 mg/kg(groupⅢ),lidocaine 2mg/kg (groupⅣ).Toxic symptoms of lidocaine were recorded within lmin after the administration of lidocaine,then fentanyl 3?g/ kg was given intravenously within 5 seconds.Cough incidence and cough grade were recorded within 2rain after the administration of fentanyl.Systolic blood pressure (SBP),diastolic blood pressure (DBP),heart rates (HR),and satu- ration of pulse oximeter(SpO2) were recorded during different time points of induction,all recorded data were anal- ysed by the statistical software,P value
