The relationship between expression of cyclooxygenase-2,vascularendotheliai growth factor and angiogenesis in hepatoceUular carcinoma
- VernacularTitle:肝癌组织中环氧合酶-2血管内皮生长因子表达与肿瘤血管生成的关系
- Author:
Dong-Mei ZOU
;
Qing-Xu YANG
;
Tong-Tong WU
;
- Publication Type:Journal Article
- Keywords:
Cyclooxygenase-2;
Vascular endothelial growth factor;
Liver neoplasms
- From:
Chinese Journal of Primary Medicine and Pharmacy
2006;0(08):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the significance of cyclooxygenase-2 (COX-2),vascular endothelial growth factor(VEGF) protein expression and angiogenesis in hepatocellular carcinoma(HCC).Methods Tissue sec- tions from 40 HCC patients were examined immunohistochemically for protein expression of COX-2 and VEGF.Mi- crovessel density(MVD) was counted by endothelial cells immunostained by anti-CD34 antibody.Results The ex- pression of COX-2 protein in well differentiated HCC was stronger than that in moderately differentiated HCC and poorly differentiated HCC(P
