The Expression and Clinical Significance of C-kit、C-abl and PDGFR? in Ovarian Carcinoma
- VernacularTitle:卵巢癌中C-kit、C-abl、PDGFR?的表达及意义
- Author:
Leina WANG
;
Xiaoyu TIAN
;
Jianqiang MI
;
Yunhong GUO
;
Lili XIONG
;
- Publication Type:Journal Article
- Keywords:
Ovary carcinoma;
C-kit;
C-abl;
PDGFR?;
Therapeutic application
- From:
Journal of Medical Research
2006;0(08):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective This study was to examine the expression of tyrosine kinase receptor(TKRs)C-kit,C-abl and PDGFR?,in ovary carcinoma.Methods The expression of C-kit,C-abl and PDGFR? in tumor tissue of 60 specimens of ovary carcinoma and normal fissue of 20 specimens of overy was examined by immunohistochemistry SP method.Results Immunoreactivity was detected in 79% of the tumor to at least one TKR.The total positive expression rate of C-kit,C-abl and PDGFR? in ovary carcinoma was 58.3%,70%,73.3%,respectively.The positive expression rate of C-kit and PDGFR? is significantly higher in tumor tissues than in normal tissues(P
