Effects of compound nutrients on changes in serum stress-induced IL-6 levels in rats
- VernacularTitle:复合营养素对应激大鼠血清IL-6水平的影响
- Author:
Yali LIU
;
Sumin CHI
;
Hui BI
;
- Publication Type:Journal Article
- Keywords:
compound nutrients;
interleukin-6;
stress
- From:
Medical Journal of Chinese People's Liberation Army
2001;0(08):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the effects of compound nutrients on serum concentrations of IL-6 induced by immobilization and cold water-immersion in rats.Methods Stress was produced by immobilization and cold water-immersion.Rats were randomly as- signed to two groups,i.e.acute and chronic stress groups.Acute stress group was divided again into normal control group(C),acute stress group(AS)and acute stress+compound nutrients group(AS+CN).Chronic stress group was assigned again into normal control group(C),chronic stress group(CS)and chronic stress+compound nutrients group(CS+CN).The serum IL-6 level was determined by enzyme-linked immunosorbent assay(ELISA).Results Oral(gavage)administration of compound nutrients may attenuate effect of stress induced by acute and chronic immobilization,and reduce the increase in serum IL-6 level induced by cold water-immersion stress.In acute immobilization and cold water-immersed stress group,the serum IL-6 level rose significantly from 17.69?0.96 to 29.67?1.64pg/ml 30 minutes after stress,and the administration of compound nutrients effectively attenuated the rise in serum IL-6 level 30 minutes after stress from 29.67?1.64 to 22.30?2.52pg/ml (P
