Effect of vitamin E on urinary 8-iso prostaglandin(PG)F_(2?) level in patients with cerebral infarction
- VernacularTitle:维生素E对脑梗死患者尿液中8-异前列腺素F_(2?)含量的影响
- Author:
Weiping GUAN
;
Peigen KUANG
;
Shengyuan YU
;
- Publication Type:Journal Article
- Keywords:
vitamin E;
8-iso prostaglandin F_(2?);
brain infarction
- From:
Medical Journal of Chinese People's Liberation Army
2001;0(08):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the effect of vitamin E administration on the urinary level of 8-iso prostaglandin F_(2?)(8-iso- PGF_(2?))in the patients with cerebral infarction.Methods 28 patiems with acute cerebral infarction were involved in this study according to the selection criteria.They were divided into two groups:patients in test group(n=14)were treated with vitamin E,and those in control group(n=14)were not treated with vitamin E.No significant differences existed in age,gender ratio,blood pressure,lipids level and lo- cation and level of the cerebral infarct focus between two groups.The contents of urinary 8-iso-PGF_(2?) were measured in each urinary speci- men,meanwhile the levels of vitamin E and low density lipoprotein(LDL)were determined in each plasma specimen within 24 hours after onset of cerebral infarct and two weeks later.Results The concentration of urinary 8-iso-PGF_(2?) collected at two weeks after onset from pa- tients of test group was significantly lower than that of the control group(85.20?9.17 vs 91.36?4.24ng/mmol creatinine,P0.05).Conclusions The content of urinary 8-iso-PGF_(2?) and the level of oxidative stress in vivo could be decreased in the patients with acute cerebral infarction after being treated with vitamin E.
