Research on the effect of valsartan on atherosclerosis in rabbits and pro-oncogenes
- VernacularTitle:缬沙坦对兔动脉粥样硬化管壁及相关基因的研究
- Author:
Qun-Li HU
;
Li CHEN
;
Juan LI
;
Su-Ping LIU
;
Yang XU
;
Li-Qun HU
;
Qi-Yun CAI
;
- Publication Type:Journal Article
- Keywords:
Valsarvan;
Atherosclerosis;
Pro-oncogene
- From:
Chinese Journal of Primary Medicine and Pharmacy
2006;0(07):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the effect of different doses valsartan on atherosclerosis in rabbits. Methods 53 white rabbits were randomly divided into control group,cholesterol group,and valsartan group of high-,middle-,and low-dose.The positive expression of pro-oncogene c-myc and c-fos mRNA was studied with in situ reverse transcription-PCR)ISRT-PCR).The histoppathological changes of aorta were observed.Results)1) Positive expression rate of pro-oncogene c-myc and c-fos mRNA was significantly higher in cholesterol than that in the qontrol group.The rate of positive expression was remarkably lower in the high-dose valsartan group than that in the cholesterol group)P
