Clinical study on YMDD mutation and pre-core C region and core promotor region mutation of the patients with chronic hepatitis B virus receiving lamivudine therapy
- VernacularTitle:慢性乙型肝炎患者YMDD变异合并前C/C区启动子变异的临床研究
- Author:
Cheng XU
;
Hui-Lin YANG
;
Lin-Mei XU
;
Hong-Yan YAO
;
Xiao-Hua LE
;
Mei-Zhong LI
;
Xiao-Ling JIANG
;
Ju-Zhen ZHONG
;
Min WANG
;
Huo-Sheng WANG
;
Boping ZHOU
- Publication Type:Journal Article
- Keywords:
Lamivudine;
Chronic HBV;
YMDD mutation;
Pre-core C region mutation;
Basal core promotor region mutation
- From:
Chinese Journal of Primary Medicine and Pharmacy
2006;0(07):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To mvesugate the Tate of YMDD mutation accompamed with pre-core(region and core promotor region mutation and the clinical significance.Methods YMDD mutation and pre-core(at 1896 nu- cleotide)region and core promotor region(at 1762.1764 nucleotide)mutation were detected from the 122 patients with chronic hepatitis B virus after receiving lamivudine treatment above 6 months.Results 40 cases were tested for YMDI)mutations in 122 HBV patients with lamivudine treatment,and the positive rate of YMDD mutation was 32.8 %.After YMDD mutation,ALT,AST and HBV DNA of the patients significantly increased(P0.05).Conclusion The patients with YMDD mutation had higher rate of pre-core region(at 1896 nucleotide)and basal core promotor region(at 1762, 1764 nucleotide)mutation than those without YMDD mutation,but there was no correlation between the mutation and the deterioration of disease condition and the bad prognosis.
