Clinical observation of Pre-S1 antigens in interferon combination with kurarinone therapy
- VernacularTitle:前S1抗原在干扰素联合苦参素用药中的临床观察
- Author:
Xu ZHANG
;
Jian-Huan LIAO
;
Huan-Rong ZOU
;
Yan-Feng HUANG
;
- Publication Type:Journal Article
- Keywords:
Pre S1 antigens;
HBeAg;
HBV-DNA;
Interferon;
Kurarinone
- From:
Chinese Journal of Primary Medicine and Pharmacy
2006;0(07):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the clinical significance and laboratory diagnostic values of Pre-S1 antigens (Pre-S1)and its relativity to HBeAg and HBV-DNA after using interferon in association with kurarinone.Methods The content of Pre-S1 and HBV-M was detected by ELISA and the levels of HBV-DNA were detected by flores- cence quantitative PCR(FQ-PCR)in 100 serum samples of patients with HBV infection and patients after an antivi- ral treatment.Results Matched control in 50 serum of HBsAg-positive and detectable HBV-DNA cases,both 29 samples in 30 HBeAg-positive cases and 17 samples in 20 HBeAg-negative cases Pre-S1s were positive.Treatment set 50 serum of patients after taking two courses of an antiviral treatment for HBV infection,drawing blood to observe related markers,5 cases of effect set were turned into negative for serologic markers and virologic markers.19 cases of valid set,serologic markers were various and the HBV-DNA copies descended 2-3 orders of magnitude.26 cases of invalid set,serologic markers were not various,and 30 % samples of the HBV-DNA copies descended 1～2 orders of magnitude.Conclusion It was supplementary for Pre-S1 to indicate HBV expression when the HBeAg varied.It also provided detcctable laboratory markers in HBV infectivity,replication and therapeutic efficiency evaluation.
