The impact of fatty liver and its related factors on the efficacy of antiviral therapy in patients with chronic hepatitis C
- VernacularTitle:脂肪肝及其相关因素对联合抗病毒治疗慢性丙型肝炎效果的影响
- Author:
Jian-Wu YU
;
Gui-Qiang WANG
;
Yong-Hua ZHAO
;
Shu-Chen LI
;
- Publication Type:Journal Article
- Keywords:
Hepatitis C.chronic;
Genotype;
Fatty liver;
Insulin;
Interferon alfa-2a;
Polyethylene glycols;
Ribavirin
- From:
Chinese Journal of Infectious Diseases
2007;0(07):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the impact of fatty liver and its related factors on the effi- cacy of antiviral therapy in patients with chronic hepatitis C.Methods ninety-eight patients with chronic hepatitis C were treated with 180?g peginterferon?-2a plus ribavirin.Hepatitis C virus (HCV) genotypes were measured by enzyme-linked immunosorbent assay (ELISA) and fatty liver were detected by ultra sonography.The body mass index (BMI),waist to hip ratio (WHR) and ho- meostasis model assessment of insulin resistance (HOMA-IR) were calculated.The serum HCV RNA level was determined by polymerase chain reaction (PCR) and serum insulin level was detected by chemiluminescence analysis.The impact of fatty liver and its related factors on the efficacy of antiviral therapy were analyzed by multivariate Logistic regression analysis.Results Of 98 patients with chro- nic hepatitis C,35 (35.7%) were genotype 1,41 (41.8%) were genotype 2,13 (13.3%) were gen- otype 3,9 (9.1%) were undetermined genotype.The incidence of fatty liver in HCV infection of genotype 1,2,3 and undetermined genotype was 11.4%,9.8%,38.5% and 11.1%,respectively (X~2=7.83,P
