Application of non-bioartificial liver combined with liver transplantation in treating mid-or end-stage chronic serious hepatitis
- VernacularTitle:非生物人工肝联合肝移植治疗中晚期慢性重型肝炎
- Author:
Jie XIA
;
De-Dong XIANG
;
Zhan-Yu YANG
;
Nan ZHANG
;
Peng GUO
;
Ji-Jun ZHOU
;
Yu-Ming WANG
;
- Publication Type:Journal Article
- Keywords:
Hepatitis;
viral;
human;
Liver;
artificial;
Liver transplantation
- From:
Chinese Journal of Infectious Diseases
2007;0(07):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the application of non-bioartificial liver support system (ALSS) combined with liver transplantation(LT) in treating mid-or end-stage chronic severe hepati- tis.Methods ALSS plus liver transplantation were employed in treating 28 patients with mid-or end- stage chronic severe hepatitis.Clinical data from the patients before and after treatment were collect- ed.The survive rate of ALSS plus LT group were compared with that of medication group 99 cases and medication plus ALSS group 30 cases.The data were analyzed with t test and X~2 test.Results After 57 times ALSS treatment,the serum total bilirubin(TBil),prothromin time(PT),bile acid, blood urea nitrogen(BUN),creatnine(Cr) and ammonia of all the 28 patients got improved(P 0.05).The clinical symptoms and signs of the patients were ameliorated at median 3 d(1～153 d). All patients were bridged to liver transplantation successfully after median 20 d(1～153 d).The 3 and 6 months post-operation survival rate of ALSS plus LT group(71.4%,71.4%) were significantly higher than those in medication group(18.2%,11.1%) and medication plus ALSS group(36.7%, 26.6%)(P
