Relationship between interleukin-12B gene + 1188 polymorphism and the susceptibility to hepatitis B virus intrauterine infection
- VernacularTitle:白细胞介素-12B+1188位点基因多态性与乙型肝炎病毒宫内感染的关系
- Author:
Yan-Ling GE
;
Qi-Rong ZHU
;
Jian-She WANG
;
- Publication Type:Journal Article
- Keywords:
Hepatitis B virus;
Geneotype;
Polymorphism;
single nucleotide;
Interleukin12;
Disease transmission;
vertical;
Aueles
- From:
Chinese Journal of Infectious Diseases
2007;0(07):-
- CountryChina
- Language:Chinese
-
Abstract:
10 mU/L (GroupⅡ,71 cases) when they were one year old.There were 40 healthy children in control group. The genomic DNA from the peripheral blood was extracted and polymerase chain reaction (PCR) and sequencing were employed to detect the IL-12B gene 3′UTR+1188 SNP.Results The frequency of AA,AC and CC genotype in GroupⅠwere 25.7%,44.3% and 30.0% respectively,and 36.6%, 47.9% and 15.5% in GroupⅡ,48.8%,39.0%,12.2%,in control group,respectively.The differ- ence of frequency of CC genotype and non-CC genotype between GroupⅠand GroupⅡwas significant (x~2=17.078,P
