Whole-liver MR perfusion imaging in rabbit liver VX_2 tumors:early findings of coagulative necrosis after percutaneous ethanol injection therapy
- VernacularTitle:全肝MR灌注成像早期监测肝VX_2肿瘤经皮酒精注射疗效的实验研究
- Author:
Wan-Shi ZHANG
;
Bing WU
;
Dong WANG
;
Li-Min MENG
;
Hui-Ping SHI
;
Yun-Long SONG
;
- Publication Type:Journal Article
- Keywords:
Magnetic resonance imaging;
Perfusion;
Gadolinium;
Liver neoplasm
- From:
Chinese Journal of Radiology
2001;0(07):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the value of whole-liver MR perfusion imaging(MRPI)for early detection of coagulative necrosis after percutaneous ethanol injection(PEI)in rabbit liver VX_2 tumors. Methods VX_2 tumor cell suspension was inoculated into rabbit liver and liver VX_2 tumors[diameter of (2.6?0.6)cm]were induced in 10 male rabbits.MR T_1 WI and T_2 WI were performed to monitor the development of the liver tumor on the 2~(nd)and 3~(rd)week after inoculation.Whole-liver MRPI was performed in the 10 rabbits with liver VX_2 tumors before and 6 days after PEI therapy(1.0 ml ethanol was injected into the most enhanced tumor region under CT guiding).Signal intensity(SI)values of untreated tumor parts and treated areas 6 days after PEI were recorded respectively.The steepest slope(SS)and bolus arrival time (TO)of SI-time curves were measured.The t-Student test was used in statistical analysis of the data.Results There was significant difference in MRPI data between untreated tumor parts[TO:(16.0?1.2)s and SS: 38.9?2.2]and treated areas[TO:(50.8?5.9)s and SS:6.0?1.2]6 days after PEI(t was 15.8 and -39.6 respectively,P
