Expression of chemokines and chemokine receptors in organ-graft rejection:recent progress
- VernacularTitle:移植排斥反应中趋化因子及其受体表达的研究进展
- Author:
Liang XIAO
;
Hong FU
;
Guo-Shan DING
;
- Publication Type:Journal Article
- Keywords:
chemotactic factors;
receptors,chemokine;
organ transplantation;
graft rejection
- From:
Academic Journal of Second Military Medical University
1985;0(06):-
- CountryChina
- Language:Chinese
-
Abstract:
Acute and chronic graft rejection are the major factors leading to graft non-function.There is an active expression of chemokines early after transplantation.They recruit T cells and antigen presenting cells selectively to the graft, leading to inflammatory reaction and finally to graft non-function.Accordingly,monitoring the expression status of chemokines and their receptors regularly may help to the diagnose rejection.To determine one or more chemokines or their receptors as the new targets for anti-rejection therapy will be of great clinical significance.This review focuses on the research progression in the above areas.
