Mechanism of liver and lung injury in septic mice
- VernacularTitle:脓毒症小鼠肝肺损伤机制的研究
- Author:
Chuan-Bo ZANG
;
Rong-Qian WU
;
Xu-Hua SONG
;
Ying-Xin XU
;
Rong LI
;
- Publication Type:Journal Article
- Keywords:
sepsis;
liver injury;
lung injury;
apoptosis
- From:
Academic Journal of Second Military Medical University
1985;0(06):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the mechanism of liver and lung injury in mouse septic models.Methods:Twenty-four male Kunming mice were subjected to cecal ligation and puncture(CLP)or sham operation.The permeability of microvasculature,water contents,activities of myeloperoxidase(MPO)and the apoptosis of microvascular endothelial cells in lung microvasculature and liver sinus were examined 3 h and 12 h after operation.Results:Both the liver and lung showed a significant increase in microvessel permeability at 12 h in CLP group compared with sham operation group.MPO activity and water content in CLP group were obviously higher than those in the sham operation group.The apoptosis of lung microvascular endothelial cells at 12 h in CLP group(5.03?0.92)% was significantly higher than that of control group(3.48?1.21)%(P