Diffusion tensor imaging of brain in relapsing neuromyelitis optica
- VernacularTitle:复发性视神经脊髓炎脑扩散张量成像研究
- Author:
Chun-Shui YU
;
Kun-Cheng LI
;
Fu-Chun LIN
;
Tian-Zi JIANG
;
Wen QIN
;
- Publication Type:Journal Article
- Keywords:
Neuromyelitis optica;
Brain damage,chronic;
Magnetic resonance imaging
- From:
Chinese Journal of Radiology
1994;0(06):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the presence of occult brain tissue damage in patients with relapsing neuromyelitis optica(RNMO)and its possible mechanism by using diffusion tensor imaging (DTI).Methods DTI scans were performed in 16 patients with RNMO and 16 sex-and age-matched healthy controls.Histogram analysis of mean diffusivity (MD)and fractional anisotropy (FA)was performed in brain tissue (BT),white matter (WM)and gray matter (GM)to detect the presence of occult brain tissue damage in RNMO patients.Region of interest(ROI )analysis of MD and FA was also performed in 6 dedicated regions with or without direct connection with spinal cord or optic nerve to determine the relationship between occult brain tissue damage and the damage of spinal cord and optic nerve.Results Patients with RNMO had a significantly higher average MD of the BT[RNMO(0.95?0.02)? 10~(-3)mm~2/s,controls (0.91?0.03)?10~(-3)mm~2/s,t = 3.940,P
