MRI evaluation of cerebral perfusion change in pediatric patients with Leigh's syndrome
- VernacularTitle:MRI评价亚急性硬化性脑脊髓病患儿的脑灌注特点
- Author:
Sheng XIE
;
Zhao-Yue QI
;
Jiang-Xi XIAO
;
Yan-Ling YANG
;
Xue-Xiang JIANG
;
- Publication Type:Journal Article
- Keywords:
Leigh disease;
Magnetic resonance imaging;
Regional blood flow;
Brain
- From:
Chinese Journal of Radiology
1994;0(06):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To detect the change of cerebral perfusion in pediatric patients with Leigh's syndrome (LS)by using MR perfusion technique.Methods Twelve patients with Leigh's syndrome and thirteen normal children were scanned with the sequence of flow-sensitive alternating inversion recovery exempting separate T_1 measurement (FAIREST).Their relative cerebral blood flow(rCBF)values were obtained in regions of bilateral basilar nuclei and bilateral thalami.Student t-test was used to compare them between the two groups and receiver operating characteristic(ROC)curve analysis was carried out.Results Statistical analysis revealed significant difference between two groups in the regions of bilateral basilar nuclei and right thalamus(t =3.26,P =0.002;t =2.25 ,P =0.018 ;t =2.88 ,P =0.004,respectively).The rCBF values for LS group and control group were 0.432?0.158 and 0.619?0.125 for right basilar nuclear, 0.478?0.186 and 0.621?0.123 for left basilar nuclear,0.630?0.189 and 0.833?0.160 for right thalamus,respectively.The areas under the ROC curves were 0.833 and 0.756 for the rCBF of right and left basilar nuclear,respectively.Conclusion Relative CBF maps may reveal changes of cerebral blood flow in some specific brain regions in patients with Leigh's syndrome.It can provide additional information to the clinicians in the evaluation of the disease.
