Nitric oxide content and blood flow in nasal mucosa of allergic rhinitis guinea pigs
- VernacularTitle:变应性鼻炎豚鼠鼻黏膜组织中一氧化氮含量与血流量的相关研究
- Author:
Su-Min WANG
;
Hong-Liang ZHENG
;
Ru-Xin ZHANG
;
Zhao-Ji LI
;
Shui-Miao ZHOU
;
- Publication Type:Journal Article
- Keywords:
rhinitis,allergic,perennial;
nasal mucosa;
blood flow;
nitric oxide
- From:
Academic Journal of Second Military Medical University
1985;0(05):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To examine the expression of nitric oxide synthase(NOS),the content of nitric oxide and blood flow in nasal mucosa of allergic rhinitis guinea pigs,so as to further investigate the mechanism of allergic rhinitis.Methods:One hundred and twenty guinea pigs were randomly divided into control group(injected with normal saline)and allergic group(nasal challenge with egg albumin).The guinea pigs were executed before and immediately,24,48,72 h after the last nasal challenge;the expression of endothelial nitric oxide synthase(eNOS)and inducible nitric oxide synthase(iNOS)and the content of nitric oxide were examined in mucosa tissues.The blood flow in the nasal mucosa was determined in animals before execution.Linear regression correlation was used to analyze the relationship between the nitric oxide content and blood flow in nasal mucosa.Results:The immunostaining for iNOS in surface epithelium of allergic rhinitis guinea pigs was markedly stronger than that of normal guinea pigs at all time points(P
