In vivo detection of Alzheimer senile plaques by MR microscopy in transgenic mice
- VernacularTitle:MR显微成像检测活体阿尔茨海默病转基因小鼠老年斑沉积的效果
- Author:
Xue-Mei HU
;
Dao-Yu HU
;
Dong WANG
;
Su-Ming ZHANG
;
Zhen LI
;
Gui-Huan DU
;
Zu-Li LIU
;
Li WEI
;
Hao LEI
;
- Publication Type:Journal Article
- Keywords:
Magnetic resonance imaging;
Alzheimer disease;
Mice,transgenic
- From:
Chinese Journal of Radiology
2001;0(05):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective MR microscopy technique was used to study the visualization of senile plaque deposition in brains of the Alzheimer disease(AD)transgenic mice.Methods Two transgenic mice and 2 wild type mice at the age of 17 months were scanned in vivo using T_2 weighted image.After MR imaging,the brains were cut serially and immunostained according to the orthogonal pilot images.MR T_2 weighted images and immunohistological images of the senile plaque were observed and matched.Results The MR images showed that some black spots were visible in the hippocampus and cerebral cortex of the AD transgenic mice and some spots were consistent with the senile plaques on immunohistological sections.There were no spots in the MR images and the immunohistological sections of the wild type mice.Conclusion It is possible that MR microscopy can be used to detect the deposition of the senile plaque and diagnose AD specifically.
