The effect of ginkgolides on expression of ChAT in the Alzheimers disease-like rat brain
- VernacularTitle:银杏内酯对拟AD模型大鼠空间学习记忆能力和脑内ChAT表达的影响
- Author:
Qing-Chun LI
;
Tian-Sheng JIANG
;
Xin-Rui LV
;
Ya PAN
;
Nai-Chang JIANG
;
- Publication Type:Journal Article
- Keywords:
ginkgolides;
learning and memory;
nicotinic acetylcholine receptors;
choline acetyl-transferase
- From:
Chinese Pharmacological Bulletin
1986;0(04):-
- CountryChina
- Language:Chinese
-
Abstract:
Aim To investgate the mechnism through which ginkgolides affect learning and memory capabilities of the Alzheimers disease-like rats. Methods Okadaic acid(OA)was injected into the CA1 region of the rat hippocampus and the rats were gavaged with ginkgolides. The learning and memory abilities of the rats were assessed through Morris water maze behavioral test, and the expressions of nicotinic acetylcholine receptors and ChAT were observed by Western blotting and immunohistochemistry, respectively.Results Compared with the control rats, the capabilities of learning and memory were lowered significantly(P
