Pneumocystis carinii pneumonia in 12 patients with autoimmune diseases
- VernacularTitle:自身免疫病并发卡氏肺孢子菌肺炎的临床分析
- Author:
Wen-Jie ZHENG
;
Hai-Cheng SONG
;
Yan ZHAO
;
Xiao-Feng ZENG
;
Feng-Chun ZHANG
;
Fu-Lin TANG
;
- Publication Type:Journal Article
- Keywords:
Autoimmune diseases;
Pneumonia,pneumocystis;
T-lymphocyte subsets
- From:
Chinese Journal of Infectious Diseases
1997;0(04):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the clinical features of pneumocystis carinii pneumonia (PCP)in patients with autoimmune diseases.Methods The data from 12 patients with autoimmune diseases who were hospitalized in Peking Union Medical College Hospital because of developing PCP were retrospectively reviewed.Clinical characteristics and T cell subsets in the peripheral blood were analyzed.Results The main clinical manifestations of these 12 patients were fever(12/12),cough(9/ 12),expectoration(9/12)and obvious dyspnea(12/12),which were progressive.Blood gas analysis presented with typeⅠrespiratory failure.Bilateral interstitial and alveolar infiltrates were observed in chest X-ray film.The counts of peripheral blood lymphocytes(0.44?0.31)?10~9/L,CD4~+ T-lymphocytes (0.120?0.079)?10~9/L and CD8~+ T-lymphocytes were(0.248?0.252)?10~9/L decreased significantly and the CD4/CD8 ratio reversed,which were significantly different from those of healthy person(P
