Effects of Saponin Extracted from Zea Mays L (ZMLS) on Pathogenic Diabetic Mouse Model Caused by Administration of Alloxan and Glucose
- VernacularTitle:玉米须总皂苷对四氧嘧啶加葡萄糖所致小鼠病因性糖尿病模型的影响
- Author:
Mingsan MIAO
;
Yanhong SUN
;
Xiaoning JI
;
Huili LIU
;
- Publication Type:Journal Article
- Keywords:
Saponin Extracted from Zea Mays L(ZMLS);
pathogenic diabetic mouse model;
alloxan
- From:
China Journal of Traditional Chinese Medicine and Pharmacy
2005;0(03):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To observe the effects of Saponin Extracted from Zea Mays L(ZMLS) on reducing blood sugar in pathogenic diabetic mouse models.Methods: The pathogenic diabetic mouse models were established successfully by intravenous injection of small dose of alloxan and intragastric administration of glucose.Modeling state of pathogenic diabetic mice and the effects of Saponin Extracted from Zea Mays L(ZMLS) on pathogenic diabetic mouse models were observed through the levels of blood sugar and serum of insulin and the pathology changes of islet cells.Results: It was successful to establish pathogenic diabetic mouse models by intravenous injection of small dose of alloxan and intragastric administration of glucose.ZMLS had good action of lowering the level of blood glucose on this model and had good action of preventing the pancreatic island ?-cell from the injury induced by drugs.Conclusion: ZMLS has good therapy effects on pathogenic diabetic mouse models induced by intravenous injection of small dose of alloxan and intragastric administration of glucose.
