Integration of pharmacokinetics and pharmacodynamics in antibiotic drug development and pharmacotherapy
- VernacularTitle:药物动力学和药效动力学在抗菌药物新药开发和临床治疗上的应用
- Author:
Jun SHI
;
- Publication Type:Journal Article
- Keywords:
pharmacokinetics;
pharmacodynamics;
antibiotic;
in vitro kinetic model;
Monte Carlo simulation
- From:
Chinese Journal of Clinical Pharmacology and Therapeutics
2000;0(02):-
- CountryChina
- Language:Chinese
-
Abstract:
Integration of pharmacokinetics(PK)/pharmacodynamics(PD)in antibiotic drug development allows the dosage regimen to be optimized,so that the desired effect can be achieved in a large proportion of the target patient population.In vitro kinetic and in vivo animal models have been extensively used in the evaluation of antibiotics.The value of these pre-clinical models in the PK and PD characterization of antibiotics is critically reviewed.A model based clinical development of antibiotics with integrating MIC distribution,PK parameter distribution,the PD target from animal models of infection,and the protein binding of the test drug,is also reviewed.
