Protective Effects of Gastrodine on Cultivated Rat Brain Microvessel Endothelial Cells by Mimic Cerebral Ischemia
- VernacularTitle:天麻素对体外模拟脑缺血损伤大鼠脑微血管内皮细胞的保护作用
- Author:
Jinghong HU
;
Yinchu SI
;
Qingtao HONG
;
Xiang HUANG
;
Yipeng TANG
;
Xuemei QING
;
Pengtao LI
;
- Publication Type:Journal Article
- Keywords:
Gastrodine;
cerebral ischemia;
brain microvessel;
endothelial cell;
MTT method;
NO
- From:
China Journal of Traditional Chinese Medicine and Pharmacy
2005;0(02):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To observe the protective effects of Gastrodine on the cultivated rat brain microvessel endothelial cells damage by mimic cerebral ischemia.Methods: The endothelial cells activity,survival rate,the change in NO content,and the effects of Gastrodine were observed in the cultivated rat brain microvessel endothelial cells(BMEC) damaged by mimic cerebral ischemia.Results: The activity and survival rate of BMEC in the ischemia groups are obviously lower than that in the normal groups;compared with the normal groups,the activity,survival rate and NO content of BMEC in the Gastrodin groups have the increasing tendency;comparing to the ischemia groups,the activity of BMEC in the Gastrodin groups obviously increasing(P
